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By blocking NF-ΞΊB, KPV reduces the production of pro-inflammatory cytokines (IL-1Ξ², TNF-Ξ±, IL-6) and inflammatory mediators (PGE2, NO)
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Moreover, it resulted peripherally restricted, with brain-to-plasma ratio of 0.005 after 7 h, and undetectable brain exposure after 24 h
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